Jeong LAB

At the Jeong lab, we are dedicated to exploring the intricate mechanisms underlying aging and the aging process. Our research aims to unravel the complex biological pathways that contribute to age-related diseases, cellular senescence, and tissue integrity. By understanding these processes, we strive to develop innovative strategies to promote healthy aging and combat the adverse effects of aging on human health.

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 <Our Research Focus>

Aging is a multifaceted phenomenon that affects all living organisms, leading to a gradual decline in physiological functions and an increased susceptibility to diseases. Our lab focuses on investigating the cellular and molecular foundations of aging, particularly the role of cellular senescence—a state of irreversible cell cycle arrest that occurs in response to various stressors. By studying the triggers and consequences of senescence, we aim to identify therapeutic targets that can delay or prevent the onset of age-related pathologies. Here are our main research goals. 

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1.  Aging Processes and Age-Related Diseases

Age-related diseases, such as cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes, pose significant challenges to public health. Our research seeks to understand the connections between aging and these diseases, with an emphasis on how cellular senescence and other aging-related processes contribute to their development. Through our studies, we hope to uncover novel biomarkers and therapeutic interventions that can mitigate the impact of these conditions on the aging population.

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2.  Senescence and Therapeutic Interventions

Cellular senescence is not only a hallmark of aging but also a contributor to tissue dysfunction and inflammation. Our lab investigates the mechanisms by which senescent cells influence their microenvironment and drive age-related tissue damage. Additionally, we explore therapeutic interventions, such as senolytic drugs and senomorphic agents, that can selectively eliminate or modify senescent cells to restore tissue homeostasis and improve healthspan.

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3.  Therapy-Induced Senescence (TIS)

In our pursuit of understanding senescence, we also delve into Targeted Induced Senescence (TIS), a promising area of research with potential applications in cancer therapy and tissue regeneration. By inducing senescence in cancer cells, we aim to halt tumor progression and enhance the efficacy of existing treatments. Furthermore, we investigate how controlled induction of senescence in specific cell types can aid in tissue repair and rejuvenation, offering new avenues for regenerative medicine.

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4.  Rejuvenation and Healthy Aging

Our ultimate goal is to contribute to the field of rejuvenation and promote healthy aging. By identifying key factors that drive the aging process and developing interventions to counteract them, we aspire to extend healthspan and improve the quality of life for the aging population. Our multidisciplinary approach combines cutting-edge technologies, collaborative research, and a commitment to scientific excellence to pave the way for breakthroughs in aging research and therapeutic innovation.