top of page
Research

Cells or organisms encounter many internal and external stresses, which may cause the accumulation of damage to DNA, proteins and lipids. To respond to these threats, cells have evolved the stress response and repair pathways ranging from the activation of survival/repair pathways to the initiation of cell death, and defects in these critical cellular responses are frequent causes of human pathologies, like neurodegenerative diseases, diabetes, heart diseases, cancers and aging

Whereas increasing evidence supports the idea that metabolic changes underlie many cell-fate decisions and adaptive cellular responses, but the fundamental question about the cellular metabolic response to stresses remain largely unknown, impeding the development of metabolic interventions that might delay and prevent cancer and age-related diseases.

Our lab is interested in understanding the mechanisms that ensure cellular fitness upon stresses. The main goals of our research are: 1) in the context of cancer with the aim of understanding how metabolic stress response contributes to tumorigenesis and cancer progression and 2) in the context of aging, with the aim of deciphering the basis of age-induced defects of stress response pathways within the frame of metabolism. These studies have tremendous implications for the understanding the pathogenesis of disease and aging processes, and may lead to new therapeutic strategies that could treat a spectrum of human disease and aging.

bottom of page